Peng Wu (grad student in statistics)

will present the paper

"Applications of reliability coefficients
 in cDNA microarray data analysis"

by He et al., Statist. Med. 2006; 25:1051-1066



Abstract:

Gene expression microarray technology has been widely used in areas such
as human cancer research to identify molecular characteristics of sample
specimens. The microarray study, however, is a very complicated procedure
which involves numerous sources of variability that may be either
systematic or random. Systematic variation is often eliminated by applying
normalization procedures, but at present there are no standard criteria
available to evaluate the performance of a particular normalization
approach. In this paper, we propose a reliability-type coefficient as a
criterion to assess the effectiveness of normalization procedures in
eliminating systematic variation. Simulation studies show that this
criterion performs reasonably well in a range of settings. The proposed
method is illustrated using a subset of an ongoing microarray study of
soft-tissue sarcoma.